Considering the pulsatile nature of insulin, is a measure of triglycerides a more effective measure of insulin resistance? TyG Index?

Triglycerides, especially when combined with glucose levels in the form of the triglyceride-glucose (TyG) index, are considered a reliable and cost-effective marker of insulin resistance.

The TyG index, calculated using fasting triglyceride and glucose levels, correlates strongly with the gold-standard insulin resistance measures like the hyperinsulinemic-euglycemic clamp and the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). This makes it a non-invasive and practical tool to assess insulin resistance in clinical settings.

Studies suggest that elevated triglyceride levels, particularly when combined with low HDL cholesterol, reflect metabolic disturbances associated with insulin resistance. The TyG index has been found to be more predictive of insulin resistance than some other common metrics like HOMA-IR and is associated with cardiovascular risks and conditions like non-alcoholic fatty liver disease (NAFLD)   .

You can explore one of these studies on PubMed here: TyG index and insulin resistance correlation. https://lipidworld.biomedcentral.com/articles/10.1186/s12944-016-0324-2