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Weight Loss Difficulty Scale

Visit this link on "Insulin Resistance Progression" for the bigger picture:

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The TyG index and TG/HDL ratio can be used as objective metabolic indicators to show the gap between someone’s Metabolic Archetype™ and their current metabolic state. It also makes sense to link these markers to the difficulty of weight loss, reinforcing the idea that metabolic health must improve before sustainable fat loss becomes feasible.

 

Using TyG Index as a Weight Loss Difficulty Scale

 

The TyG index (log[fasting TG (mg/dL) × fasting glucose (mg/dL) / 2]) is already well-correlated with insulin resistance. Since insulin resistance inhibits lipolysis, a high TyG index could directly predict:

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  • How much effort is required to lose fat

  • How much carbohydrate tolerance is impaired

  • How sensitive someone is to meal timing and macronutrient balance

  • The necessity of fasting or ketogenic strategies to first correct metabolic dysfunction before effective fat loss can occur

Insulin resistance and weight management relationship:

The key factors illustrating the relationship between insulin resistance and weight management are:

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  1. Fasting Insulin & HOMA-IR: Insulin resistance can be quantified using fasting insulin, HOMA-IR, or other indices like the TyG index. These markers can help define different levels of insulin resistance.

  2. Basal Metabolic Rate (BMR) & Energy Expenditure: Insulin resistance can alter metabolic rate by affecting mitochondrial efficiency, thyroid function, and metabolic flexibility.

  3. Carbohydrate & Fat Utilization: Insulin-resistant individuals often struggle with carbohydrate metabolism and may be more prone to fat storage instead of oxidation.

  4. Adipose Tissue Partitioning: Higher insulin levels tend to promote fat storage, particularly visceral fat accumulation, which is more metabolically active and further drives insulin resistance.

  5. Glucose & Lipid Response: Postprandial glucose and triglyceride excursions could be incorporated to assess how well someone manages energy intake and substrate utilization.

  6. Dietary Response & Macronutrient Sensitivity: Some individuals with insulin resistance manage weight better on low-carb or ketogenic diets, while others may require different strategies.

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